Skip to content


  • Add this article to your LinkedIn page
  • Add this article to your Twitter feed
  • Add this article to your Facebook page
  • Email this article
  • View or print a PDF of this page
  • Share further
  • Add this article to your Pinterest board
  • Add this article to your Google page
  • Share this article on Reddit
  • Share this article on StumbleUpon
  • Bookmark this page

New diagnostic tests: why a focus on accuracy and precision is key


Diagnostic technologies will increasingly take centre stage as new technologies and increasing cost pressures combine to reshape the way healthcare is delivered.

For example, it is anticipated that diagnostic tests will play an important role in stratifying patients into different disease sub-groups to enable more targeted (and cost-effective) treatment.  Also, the drive to reduce the length of hospital stays will mean more people with chronic conditions will be cared for at home with remote monitoring technologies helping physicians to track the patient’s condition.

New challenges on accuracy and precision

Many of the new diagnostic technologies will be used in the relatively uncontrolled environments – compared to traditional clinical laboratories – of the patient’s home or the doctor’s office. In addition to the challenge provided by the environment, the range and type of samples and the variable skill levels of the user will all provide challenges  to the reliability of the test and the accuracy and precision it can deliver. 

Of course, the regulatory process ensures that only diagnostic tests with acceptable levels of sensitivity, specificity, accuracy and precision are approved for use.  However, a recent report on blood glucose monitoring (BGM) systems -  the most widespread and well established self-test diagnostic - suggests that while this might be true for diagnostic tests carried out under laboratory, or simulated user, environments, in the hands of real users and conditions, diagnostic test results can be inaccurate. 

So whilst innovative manufacturers of modern BGM systems have made enormous strides in improving the convenience of use (reduced blood volume requirement, shorter time to result, smaller meters, integrated meters housing test strips etc.), equivalent progress on accuracy and precision in real-world diagnostic performance has not been as evident.

A new approach to improving diagnostic accuracy and precision

Looking forward, the question is how can manufacturers of existing and new self-test and point-of-care diagnostic tests improve real-life diagnostic accuracy and precision? 

One approach, for which PA has been granted a patent, is where a small, known quantity of the target analyte is added to the test sample on the disposable part of the system to quantify the sample matrix effects. This approach has broad applicability and should enable correction for a number of potential sources of inaccuracy.

In our view, balancing enhancements in diagnostic performance with continued focus on user convenience will encourage market growth and will help realise the full potential of diagnostics in the reshaped healthcare environment.

If you would like to know more about PA’s patented approach to improving diagnostic accuracy and precision, please contact us

By using this website, you accept the use of cookies. For more information on how to manage cookies, please read our privacy policy.